A Mathematical Model for Predicting Obesity Transmission with Both Genetic and Nongenetic Heredity.

ABSTRACT:

Objective

Obesity is transmissible across generations through both genetic and nongenetic routes, but distinguishing between these factors is challenging. This study aimed to quantitatively examine the contribution of these genetic and nongenetic effects to assess their influence on obesity prevalence.

Methods

A mathematical model was proposed that incorporated both the genetic and nongenetic effects of obesity. Model parameters were estimated by using observational data. Model simulations were used to assess the sensitivity of model parameters. To strengthen the study's approach, parameter estimation and simulation using data from the United Kingdom were also performed.

Results

Individuals homozygous for a "hypothetical obesogenic gene" were suggested to be more susc

SUBMITTER: Ejima K 

PROVIDER: S-EPMC5916034 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature