Inflammatory monocytes contribute to the persistence of CXCR3^hi CX3CR1^lo circulating and lung-resident memory CD8⁺ T cells following respiratory virus infection.

ABSTRACT: Phenotypically diverse memory CD8⁺ T cells are present in the lungs that either re-circulate or reside within the tissue. Understanding the key cellular interactions that regulate the generation and then persistence of these different subsets is of great interest. Recently, DNGR-1⁺ dendritic cell (DC) mediated priming was reported to control the generation of lung-resident but not circulating memory cells following respiratory viral infection. Here, we report an important role for Ly6C⁺ inflammatory monocytes (IMs) in contributing to the persistence of memory CD8⁺ T cells but not their generation. Effector CD8⁺ T cells expanded and contracted normally in the absence of IMs, but the memory compartment declined significantly over time. Q

SUBMITTER: Desai P 

PROVIDER: S-EPMC5916332 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature