Genomewide Association Study of Alcohol Dependence and Related Traits in a Thai Population.

ABSTRACT:

Background

Alcohol use (both quantity and dependence) is moderately heritable, and genomewide association studies (GWAS) have identified risk genes in European, African, and Asian populations. The most reproducibly identified risk genes affect alcohol metabolism. Well-known functional variants at the gene encoding alcohol dehydrogenase B and other alcohol dehydrogenases affect risk in European and African ancestry populations. Similarly, variants mapped to these same genes and a well-known null variant that maps to the gene that encodes aldehyde dehydrogenase 2 (ALDH2) also affect risk in various Asian populations. In this study, we completed the first GWAS for 3 traits related to alcohol use in a Thai population recruited initially for studies of methamphetamine dependence.

Met

SUBMITTER: Gelernter J 

PROVIDER: S-EPMC5916336 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature