Neuropsychiatric Phenotypes Produced by GABA Reduction in Mouse Cortex and Hippocampus.

ABSTRACT: Whereas cortical GAD67 reduction and subsequent GABA level decrease are consistently observed in schizophrenia and depression, it remains unclear how these GABAergic abnormalities contribute to specific symptoms. We modeled cortical GAD67 reduction in mice, in which the Gad1 gene is genetically ablated from ~50% of cortical and hippocampal interneurons. Mutant mice showed a reduction of tissue GABA in the hippocampus and cortex including mPFC, and exhibited a cluster of effort-based behavior deficits including decreased home-cage wheel running and increased immobility in both tail suspension and forced swim tests. Since saccharine preference, progressive ratio responding to food, and learned helplessness task were normal, such avolition-like behavior could not be explained by anhedonia or

SUBMITTER: Kolata SM 

PROVIDER: S-EPMC5916365 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature