Dopamine Receptor-Specific Contributions to the Computation of Value.

ABSTRACT: Dopamine is thought to play a crucial role in value-based decision making. However, the specific contributions of different dopamine receptor subtypes to the computation of subjective value remain unknown. Here we demonstrate how the balance between D1 and D2 dopamine receptor subtypes shapes subjective value computation during risky decision making. We administered the D2 receptor antagonist amisulpride or placebo before participants made choices between risky options. Compared with placebo, D2 receptor blockade resulted in more frequent choice of higher risk and higher expected value options. Using a novel model fitting procedure, we concurrently estimated the three parameters that define individual risk attitude according to an influential theoretical account of risky decision making (p

SUBMITTER: Burke CJ 

PROVIDER: S-EPMC5916370 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature