Oncogene mutational analysis in Chinese gastrointestinal stromal tumor patients.

ABSTRACT:

Background

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors and exhibit a high frequency of oncogenic KIT or PDGFRA mutations. Tyrosine kinase inhibitors (TKIs) have been mainly used in the treatment of GISTs bearing KIT/PDGFRA mutations. However, other mutation profiles have been found to affect the sensitivity to and effectiveness of TKIs in the treatment of GISTs.

Purpose

The aim of the present study was to describe the mutational status of multiple genes in GIST samples and to provide information for finding potential predictive markers of therapeutic targets in Chinese GIST patients.

Patients and methods

MassARRAY spectrometry was used to test 40 Chinese GIST patients for 238 mutations affecting 19 oncogenes.

SUBMITTER: Chen Q 

PROVIDER: S-EPMC5916380 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature