Glucose Sensing with Phenylboronic Acid Functionalized Hydrogel-Based Optical Diffusers.

ABSTRACT: Phenylboronic acids have emerged as synthetic receptors that can reversibly bind to cis-diols of glucose molecules. The incorporation of phenylboronic acids in hydrogels offers exclusive attributes; for example, the binding process with glucose induces Donnan osmotic pressure resulting in volumetric changes in the matrix. However, their practical applications are hindered because of complex readout approaches and their time-consuming fabrication processes. Here, we demonstrate a microimprinting method to fabricate densely packed concavities in phenylboronic acid functionalized hydrogel films. A microengineered optical diffuser structure was imprinted on a phenylboronic acid based cis-diol recognizing motif prepositioned in a hydrogel film. The diffuser structure engineered on the hydrogel

SUBMITTER: Elsherif M 

PROVIDER: S-EPMC5916466 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature