Cause-specific Mortality in a Population-based Cohort of 9799 Women Treated for Ductal Carcinoma In Situ.

ABSTRACT:

Objective

To assess cause-specific mortality in women treated for ductal carcinoma in situ (DCIS).

Background

From screening and treatment perspective, it is relevant to weigh the low breast cancer mortality after DCIS against mortality from other causes and expected mortality in the general population.

Methods

We conducted a population-based cohort study comprising 9799 Dutch women treated for primary DCIS between 1989 and 2004 and estimated standardized mortality ratios (SMRs).

Results

After a median follow up of 9.8 years, 1429 patients had died of whom 284 caused by breast cancer (2.9% of total cohort). DCIS patients <50 years experienced higher mortality compared with women in the general population (SMR 1.7; 95% confidence interval, CI: 1.4-2.0), whereas

SUBMITTER: Elshof LE 

PROVIDER: S-EPMC5916471 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature