In vivo Raman spectroscopy for biochemical monitoring of the human cervix throughout pregnancy.

ABSTRACT: BACKGROUND:The cervix must undergo significant biochemical remodeling to allow for successful parturition. This process is not fully understood, especially in instances of spontaneous preterm birth. In vivo Raman spectroscopy is an optical technique that can be used to investigate the biochemical composition of tissue longitudinally and noninvasively in human beings, and has been utilized to measure physiology and disease states in a variety of medical applications. OBJECTIVE:The purpose of this study is to measure in vivo Raman spectra of the cervix throughout pregnancy in women, and to identify biochemical markers that change with the preparation for delivery and postpartum repair. STUDY DESIGN:In all, 68 healthy pregnant women were recruited. Raman spectra were measured from the cervix

SUBMITTER: O'Brien CM 

PROVIDER: S-EPMC5916496 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature