Development of white matter microstructure in relation to verbal and visuospatial working memory-A longitudinal study.

ABSTRACT: Working memory capacity is pivotal for a broad specter of cognitive tasks and develops throughout childhood. This must in part rely on development of neural connections and white matter microstructure maturation, but there is scarce knowledge of specific relations between this and different aspects of working memory. Diffusion tensor imaging (DTI) enables us to study development of brain white matter microstructure. In a longitudinal DTI study of 148 healthy children between 4 and 11 years scanned twice with an on average 1.6 years interval, we characterized change in fractional anisotropy (FA), mean (MD), radial (RD) and axial diffusivity (AD) in 10 major white matter tracts hypothesized to be of importance for working memory. The results showed relationships between change in several tra

SUBMITTER: Krogsrud SK 

PROVIDER: S-EPMC5916522 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature