Capsaicin-enriched diet ameliorates autoimmune neuritis in rats.

ABSTRACT:

Background

Autoimmune neuropathies are common PNS disorders and effective treatment is challenging. Environmental influence and dietary components are known to affect the course of autoimmune diseases. Capsaicin as pungent component of chili-peppers is common in human nutrition. An influence of capsaicin on autoimmune diseases has been postulated.

Methods

We tested capsaicin in the animal model of experimental autoimmune neuritis (EAN) in Lewis rat. Rats were immunized with P2-peptide and were treated with capsaicin in different preventive settings. Electrophysiological, histological, and molecular biological analyses of the sciatic nerve were performed to analyze T-cell and macrophage cell count, TRPV1, and cytokine expression. Moreover, FACS analyses including the intestin

SUBMITTER: Motte J 

PROVIDER: S-EPMC5916583 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature