Genetic variants demonstrating flip-flop phenomenon and breast cancer risk prediction among women of African ancestry.

ABSTRACT:

Background

Few studies have evaluated the performance of existing breast cancer risk prediction models among women of African ancestry. In replication studies of genetic variants, a change in direction of the risk association is a common phenomenon. Termed flip-flop, it means that a variant is risk factor in one population but protective in another, affecting the performance of risk prediction models.

Methods

We used data from the genome-wide association study (GWAS) of breast cancer in the African diaspora (The Root consortium), which included 3686 participants of African ancestry from Nigeria, USA, and Barbados. Polygenic risk scores (PRSs) were constructed from the published odds ratios (ORs) of four sets of susceptibility loci for breast cancer. Discrimination capacity w

SUBMITTER: Wang S 

PROVIDER: S-EPMC5916755 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature