Targeting chemotherapy-resistant leukemia by combining DNT cellular therapy with conventional chemotherapy.

ABSTRACT:

Background

While conventional chemotherapy is effective at eliminating the bulk of leukemic cells, chemotherapy resistance in acute myeloid leukemia (AML) is a prevalent problem that hinders conventional therapies and contributes to disease relapse, and ultimately patient death. We have recently shown that allogeneic double negative T cells (DNTs) are able to target the majority of primary AML blasts in vitro and in patient-derived xenograft models. However, some primary AML blast samples are resistant to DNT cell therapy. Given the differences in the modes of action of DNTs and chemotherapy, we hypothesize that DNT therapy can be used in combination with conventional chemotherapy to further improve their anti-leukemic effects and to target chemotherapy-resistant disease.

Method

SUBMITTER: Chen B 

PROVIDER: S-EPMC5916833 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature