Novel risk genes identified in a genome-wide association study for coronary artery disease in patients with type 1 diabetes.

ABSTRACT:

Background

Patients with type 1 diabetes are more at risk of coronary artery disease than the general population. Although evidence points to a genetic risk there have been no study investigating genetic risk factors of coronary artery disease specific to individuals with type 1 diabetes. To identify low frequency and common genetic variations associated with coronary artery disease in populations of individuals with type 1 diabetes.

Methods

A two-stage genome wide association study was conducted. The discovery phase involved the meta-analysis of three genome-wide association cohorts totaling 434 patients with type 1 diabetes and coronary artery disease (cases) and 3123 T1D individuals with no evidence of coronary artery disease (controls). Replication of the top association

SUBMITTER: Charmet R 

PROVIDER: S-EPMC5916834 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature