Somatic BRCA1 mutations in clinically sporadic breast cancer with medullary histological features.

ABSTRACT:

Background

The role of somatic BRCA1/2 gene mutations in breast cancer is getting increasing attention in view of hereditary disease. The medullary phenotype and triple negative intrinsic subtypes are often, but not exclusively encountered in BRCA1 germline mutated breast cancer, whilst for BRCA2, no association to specific histological features are known. In this study, we addressed the relationship between morphological medullary phenotype and BRCA1/2 somatic mutations in breast cancer without known positive family anamnesis.

Methods

32 clinically sporadic breast cancers with medullary features were analyzed for somatic BRCA1/2 mutations (all coding exons) with next-generation sequencing technology. Paraffin-embedded formalin-fixed breast cancer samples from all patients w

SUBMITTER: Rechsteiner M 

PROVIDER: S-EPMC5916977 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature