Computer-aided biochemical programming of synthetic microreactors as diagnostic devices.

ABSTRACT: Biological systems have evolved efficient sensing and decision-making mechanisms to maximize fitness in changing molecular environments. Synthetic biologists have exploited these capabilities to engineer control on information and energy processing in living cells. While engineered organisms pose important technological and ethical challenges, de novo assembly of non-living biomolecular devices could offer promising avenues toward various real-world applications. However, assembling biochemical parts into functional information processing systems has remained challenging due to extensive multidimensional parameter spaces that must be sampled comprehensively in order to identify robust, specification compliant molecular implementations. We introduce a systematic methodology based on

SUBMITTER: Courbet A 

PROVIDER: S-EPMC5917673 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature