Neuroblastoma: clinical and biological approach to risk stratification and treatment.

ABSTRACT: Neuroblastoma is the most common extra-cranial solid tumor of childhood and the most common in the first year of life. It is a unique malignancy in that infants often present with either localized or metastatic disease that can spontaneously regress without intervention while older children can succumb to the disease after months to years of arduous therapy. Given this wide range of outcomes, the International Neuroblastoma Risk Group was created to stratify patients based on presenting characteristics and tumor biology in order to guide intensity of treatment strategies. The goal has been to decrease therapy for low-risk patients to avoid long-term complications while augmenting and targeting therapies for high-risk patients to improve overall survival. The international risk stratificati

SUBMITTER: Tolbert VP 

PROVIDER: S-EPMC5918153 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature