Ontology highlight
ABSTRACT:
SUBMITTER: Altshuler A
PROVIDER: S-EPMC5918191 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Stem cell reports 20180215 3
The transition from naive to primed state of pluripotent stem cells is hallmarked by epithelial-mesenchymal transition, metabolic switch from oxidative phosphorylation to aerobic glycolysis, and changes in the epigenetic landscape. Since these changes are also seen as putative hallmarks of neoplastic cell transformation, we hypothesized that oncogenic pathways may be involved in this process. We report that the activity of RAS is repressed in the naive state of mouse embryonic stem cells (ESCs) ...[more]