Ontology highlight
ABSTRACT:
SUBMITTER: Horvath A
PROVIDER: S-EPMC5918194 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Stem cell reports 20180208 3
Human induced pluripotent stem cell (hiPSC) cardiomyocytes (CMs) show less negative resting membrane potential (RMP), which is attributed to small inward rectifier currents (I<sub>K1</sub>). Here, I<sub>K1</sub> was measured in hiPSC-CMs (proprietary and commercial cell line) cultured as monolayer (ML) or 3D engineered heart tissue (EHT) and, for direct comparison, in CMs from human right atrial (RA) and left ventricular (LV) tissue. RMP was measured in isolated cells and intact tissues. I<sub>K ...[more]