K⁺ channel reorganization and homeostatic plasticity during postembryonic development: biophysical and genetic analyses in acutely dissociated Drosophila central neurons.

ABSTRACT: Intrinsic electric activities of neurons play important roles in establishing and refining neural circuits during development. However, how the underlying ionic currents undergo postembryonic reorganizations remains largely unknown. Using acutely dissociated neurons from larval, pupal, and adult Drosophila brains, we show drastic re-assemblies and compensatory regulations of voltage-gated (I_Kv) and Ca²⁺-activated (I_K(Ca)) K⁺currents during postembryonic development. Larval and adult neurons displayed prominent fast-inactivating I_Kv, mediated by the Shaker (Sh) channel to a large extent, while in the same neurons I_K(Ca) was far smaller in amplitude. In contrast, pupal neurons were characterized by large sustained I_Kv

SUBMITTER: Saur T 

PROVIDER: S-EPMC5918286 | biostudies-literature | 2016 Sep - Dec

REPOSITORIES: biostudies-literature