Generation and characterization of new alleles of quiver (qvr) that encodes an extracellular modulator of the Shaker potassium channel.

ABSTRACT: Our earlier genetic screen uncovered a paraquat-sensitive leg-shaking mutant quiver¹ (qvr¹), whose gene product interacts with the Shaker (Sh) K⁺ channel. We also mapped the qvr locus to EY04063 and noticed altered day-night activity patterns in these mutants. Such circadian behavioral defects were independently reported by another group, who employed the qvr¹ allele we supplied them, and attributed the extreme restless phenotype of EY04063 to the qvr gene. However, their report adopted a new noncanonical gene name sleepless (sss) for qvr. In addition to qvr¹ and qvr^EY, our continuous effort since the early 2000s generated a number of novel recessive qvr alleles, including ethyl methanesulfonate (EMS)-induced mutations qvr

SUBMITTER: Ruan H 

PROVIDER: S-EPMC5918287 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature