Endothelial TFEB (Transcription Factor EB) Positively Regulates Postischemic Angiogenesis.

ABSTRACT:

Rationale

Postischemic angiogenesis is critical to limit the ischemic tissue damage and improve the blood flow recovery. The regulation and the underlying molecular mechanisms of postischemic angiogenesis are not fully unraveled. TFEB (transcription factor EB) is emerging as a master gene for autophagy and lysosome biogenesis. However, the role of TFEB in vascular disease is less understood.

Objective

We aimed to determine the role of endothelial TFEB in postischemic angiogenesis and its underlying molecular mechanism.

Methods and results

In primary human endothelial cells (ECs), serum starvation induced TFEB nuclear translocation. VEGF (vascular endothelial growth factor) increased TFEB expression level and nuclear translocation. Utilizing genetically engineer

SUBMITTER: Fan Y 

PROVIDER: S-EPMC5918429 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature