IMPACT web portal: oncology database integrating molecular profiles with actionable therapeutics.

ABSTRACT: BACKGROUND:With the advancement of next generation sequencing technology, researchers are now able to identify important variants and structural changes in DNA and RNA in cancer patient samples. With this information, we can now correlate specific variants and/or structural changes with actionable therapeutics known to inhibit these variants. We introduce the creation of the IMPACT Web Portal, a new online resource that connects molecular profiles of tumors to approved drugs, investigational therapeutics and pharmacogenetics associated drugs. RESULTS:IMPACT Web Portal contains a total of 776 drugs connected to 1326 target genes and 435 target variants, fusion, and copy number alterations. The online IMPACT Web Portal allows users to search for various genetic alterations and connects them

SUBMITTER: Hintzsche JD 

PROVIDER: S-EPMC5918430 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature