An integrated clinical and genomic information system for cancer precision medicine.

ABSTRACT: BACKGROUND:Increasing affordability of next-generation sequencing (NGS) has created an opportunity for realizing genomically-informed personalized cancer therapy as a path to precision oncology. However, the complex nature of genomic information presents a huge challenge for clinicians in interpreting the patient's genomic alterations and selecting the optimum approved or investigational therapy. An elaborate and practical information system is urgently needed to support clinical decision as well as to test clinical hypotheses quickly. RESULTS:Here, we present an integrated clinical and genomic information system (CGIS) based on NGS data analyses. Major components include modules for handling clinical data, NGS data processing, variant annotation and prioritization, drug-target-pathway ana

SUBMITTER: Jang Y 

PROVIDER: S-EPMC5918454 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature