WISARD: workbench for integrated superfast association studies for related datasets.

ABSTRACT: BACKGROUND:A Mendelian transmission produces phenotypic and genetic relatedness between family members, giving family-based analytical methods an important role in genetic epidemiological studies-from heritability estimations to genetic association analyses. With the advance in genotyping technologies, whole-genome sequence data can be utilized for genetic epidemiological studies, and family-based samples may become more useful for detecting de novo mutations. However, genetic analyses employing family-based samples usually suffer from the complexity of the computational/statistical algorithms, and certain types of family designs, such as incorporating data from extended families, have rarely been used. RESULTS:We present a Workbench for Integrated Superfast Association studies for Related

SUBMITTER: Lee S 

PROVIDER: S-EPMC5918457 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature