Toward whole-brain dopamine movies: a critical review of PET imaging of dopamine transmission in the striatum and cortex.

ABSTRACT: The mesocorticolimbic dopamine (DA) circuit, comprising the mesolimbic and mesocortical DA pathways, plays a crucial role in reward, cognitive control, and motivation. The positron emission tomography (PET) radiotracer, [C-11]raclopride, has been used widely to image DA receptors and DA changes in the mesolimbic pathway before and after pharmacological and behavioral challenges. In certain circumstances, properties of traditional kinetic models-used to analyze dynamic PET data-are not well-suited to describing the effects of stimulus-induced DA release. To combat model shortcomings, the authors have advanced a suite of models that characterizes PET data in the presence of time-varying DA release. We review select [C-11]raclopride studies of the striatum during cigarette smoking to illustra

SUBMITTER: Liu H 

PROVIDER: S-EPMC5918462 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature