Dissemination of bla_NDM-5 gene via an IncX3-type plasmid among non-clonal Escherichia coli in China.

ABSTRACT:

Background

The emergence and spread of New Delhi metallo-β-lactamase-producing Enterobacteriaceae has been a serious challenge to manage in the clinic due to its rapid dissemination of multi-drug resistance worldwide. As one main type of carbapenemases, New Delhi metallo-β-lactamase (NDM)is able to confer resistance to almost all β-lactams, including carbapenems, in Enterobacteriaceae. Recently, New Delhi metallo-β-lactamase-5 attracted extensive attention because of increased resistance to carbapenems and widespread dissemination. However, the dissemination mechanism of bla_NDM-5 gene remains unclear.

Methods

A total of 224 carbapenem-resistant Enterobacteriaceae isolates (CRE) were collected from different hospitals in Zhejiang provinc

SUBMITTER: Li X 

PROVIDER: S-EPMC5918551 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature