Diffusivity in the core of chronic multiple sclerosis lesions.

ABSTRACT:

Background

Diffusion tensor imaging (DTI) has been suggested as a potential biomarker of disease progression, neurodegeneration and de/remyelination in MS. However, the pathological substrates that underpin alterations in brain diffusivity are not yet fully delineated. We propose that in highly cohesive fiber tracts: 1) a relative increase in parallel (axial) diffusivity (AD) may serve as a measure of increased extra-cellular space (ESC) within the core of chronic MS lesions and, as a result, may provide an estimate of the degree of tissue destruction, and 2) the contribution of the increased extra-cellular water to perpendicular (radial) diffusivity (RD) can be eliminated to provide a more accurate assessment of membranal (myelin) loss.

Objective

The purpose of this study w

SUBMITTER: Klistorner A 

PROVIDER: S-EPMC5918637 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature