Differences in White Matter Microstructure and Connectivity in Nontreatment-Seeking Individuals with Alcohol Use Disorder.

ABSTRACT:

Background

Diffusion-weighted imaging (DWI) has been widely used to investigate the integrity of white matter (WM; indexed by fractional anisotropy [FA]) in alcohol dependence and cigarette smoking. These disorders are highly comorbid, yet cigarette use has often not been adequately controlled in neuroimaging studies of alcohol-dependent populations. In addition, information on WM deficits in currently drinking, nontreatment-seeking (NTS) individuals with alcohol dependence is limited. Therefore, the aim of this work was to investigate WM microstructural integrity in alcohol use disorder by comparing matched samples of cigarette smoking NTS and social drinkers (SD).

Methods

Thirty-eight smoking NTS and 19 smoking SD subjects underwent DWI as well as structural magnetic reson

SUBMITTER: Chumin EJ 

PROVIDER: S-EPMC5919256 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature