Altered dopaminergic regulation of the dorsal striatum is able to induce tic-like movements in juvenile rats.

ABSTRACT: Motor tics are sudden, repetitive, involuntary movements representing the hallmark behaviors of the neurodevelopmental disease Tourette's syndrome (TS). The primary cause of TS remains unclear. The initial observation that dopaminergic antagonists alleviate tics led to the development of a dopaminergic theory of TS etiology which is supported by post mortem and in vivo studies indicating that non-physiological activation of the striatum could generate tics. The striatum controls movement execution through the balanced activity of dopamine receptor D1 and D2-expressing medium spiny neurons of the direct and indirect pathway, respectively. Different neurotransmitters can activate or repress striatal activity and among them, dopamine plays a major role. In this study we introduced a chronic d

SUBMITTER: Nespoli E 

PROVIDER: S-EPMC5919623 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature