Impact of different biologically-adapted radiotherapy strategies on tumor control evaluated with a tumor response model.

ABSTRACT: Motivated by the capabilities of modern radiotherapy techniques and by the recent developments of functional imaging techniques, dose painting by numbers (DPBN) was proposed to treat tumors with heterogeneous biological characteristics. This work studies different DPBN optimization techniques for virtual head and neck tumors assessing tumor response in terms of cell survival and tumor control probability with a previously published tumor response model (TRM). Uniform doses of 2 Gy are redistributed according to the microscopic oxygen distribution and the density distribution of tumor cells in four virtual tumors with different biological characteristics. In addition, two different optimization objective functions are investigated, which: i) minimize tumor cell survival (OFsurv) or; ii) max

SUBMITTER: Gago-Arias A 

PROVIDER: S-EPMC5919644 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature