A computational study of astrocytic glutamate influence on post-synaptic neuronal excitability.

ABSTRACT: The ability of astrocytes to rapidly clear synaptic glutamate and purposefully release the excitatory transmitter is critical in the functioning of synapses and neuronal circuits. Dysfunctions of these homeostatic functions have been implicated in the pathology of brain disorders such as mesial temporal lobe epilepsy. However, the reasons for these dysfunctions are not clear from experimental data and computational models have been developed to provide further understanding of the implications of glutamate clearance from the extracellular space, as a result of EAAT2 downregulation: although they only partially account for the glutamate clearance process. In this work, we develop an explicit model of the astrocytic glutamate transporters, providing a more complete description of the glutama

SUBMITTER: Flanagan B 

PROVIDER: S-EPMC5919689 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature