Glucocorticoid receptor overexpression slightly shifts microRNA expression patterns in triple-negative breast cancer.

ABSTRACT: Triple-negative breast cancer (TNBC) is a particularly aggressive subtype of breast cancer with limited options for clinical intervention. As with many solid tumors, TNBC is known to promote invasiveness and metastasis by secreting extracellular vesicles (EVs) capable of modulating the behaviour of recipient cells. Recent investigations have demonstrated that high expression levels of glucocorticoid receptor (GR) in TNBC are linked to therapy resistance, higher recurrence rates and increased mortality. In addition to activating protein-coding genes, GR is also involved in the expression of short non-coding RNAs including microRNAs (miRNAs or miRs). The molecular mechanisms responsible for the oncogenic effects of GR on TNBC have yet to be fully elucidated; however, emerging evidence sugges

SUBMITTER: Buschmann D 

PROVIDER: S-EPMC5919721 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature