Direct Testing for Allele-Specific Expression Differences Between Conditions.

ABSTRACT: Allelic imbalance (AI) indicates the presence of functional variation in cis regulatory regions. Detecting cis regulatory differences using AI is widespread, yet there is no formal statistical methodology that tests whether AI differs between conditions. Here, we present a novel model and formally test differences in AI across conditions using Bayesian credible intervals. The approach tests AI by environment (G×E) interactions, and can be used to test AI between environments, genotypes, sex, and any other condition. We incorporate bias into the modeling process. Bias is allowed to vary between conditions, making the formulation of the model general. As gene expression affects power for detection of AI, and, as expression may vary between conditions, the model explicitly takes

SUBMITTER: Leon-Novelo L 

PROVIDER: S-EPMC5919738 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature