Powerful Inference with the D-Statistic on Low-Coverage Whole-Genome Data.

ABSTRACT: The detection of ancient gene flow between human populations is an important issue in population genetics. A common tool for detecting ancient admixture events is the D-statistic. The D-statistic is based on the hypothesis of a genetic relationship that involves four populations, whose correctness is assessed by evaluating specific coincidences of alleles between the groups. When working with high-throughput sequencing data, calling genotypes accurately is not always possible; therefore, the D-statistic currently samples a single base from the reads of one individual per population. This implies ignoring much of the information in the data, an issue especially striking in the case of ancient genomes. We provide a significant improvement to overcome the problems of the D-statistic by consid

SUBMITTER: Soraggi S 

PROVIDER: S-EPMC5919751 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature