Coagulation Factor XII Levels and Intrinsic Thrombin Generation in Multiple Sclerosis.

ABSTRACT:

Background

Factor XII (FXII) activation initiates the intrinsic (contact) coagulation pathway. It has been recently suggested that FXII could act as an autoimmunity mediator in multiple sclerosis (MS). FXII depositions nearby dentritic cells were detected in the central nervous system of MS patients and increased FXII activity has been reported in plasma of relapsing remitting and secondary progressive MS patients. FXII inhibition has been proposed to treat MS.

Objective

To investigate in MS patients multiple FXII-related variables, including the circulating amount of protein, its pro-coagulant function, and their variation over time. To explore kinetic activation features of FXII in thrombin generation (TG).

Methods

In plasma from 74 MS patients and 49 healthy subjec

SUBMITTER: Ziliotto N 

PROVIDER: S-EPMC5919941 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature