Insulin-stimulated glucose uptake in skeletal muscle, adipose tissue and liver: a positron emission tomography study.

ABSTRACT:

Objective

Insulin resistance is reflected by the rates of reduced glucose uptake (GU) into the key insulin-sensitive tissues, skeletal muscle, liver and adipose tissue. It is unclear whether insulin resistance occurs simultaneously in all these tissues or whether insulin resistance is tissue specific.

Design and methods

We measured GU in skeletal muscle, adipose tissue and liver and endogenous glucose production (EGP), in a single session using ¹⁸F-fluorodeoxyglucose with positron emission tomography (PET) and euglycemic-hyperinsulinemic clamp. The study population consisted of 326 subjects without diabetes from the CMgene study cohort.

Results

Skeletal muscle GU less than 33 µmol/kg tissue/min and subcutaneous adipose tissue GU less than 11.5 µmol/kg tissu

SUBMITTER: Honka MJ 

PROVIDER: S-EPMC5920018 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature