Macrophage Lamin A/C Regulates Inflammation and the Development of Obesity-Induced Insulin Resistance.

ABSTRACT: Obesity-induced chronic low-grade inflammation, in particular in adipose tissue, contributes to the development of insulin resistance and type 2 diabetes. However, the mechanism by which obesity induces adipose tissue inflammation has not been completely elucidated. Recent studies suggest that alteration of the nuclear lamina is associated with age-associated chronic inflammation in humans and fly. These findings led us to investigate whether the nuclear lamina regulates obesity-mediated chronic inflammation. In this study, we show that lamin A/C mediates inflammation in macrophages. The gene and protein expression levels of lamin A/C are significantly increased in epididymal adipose tissues from obese rodent models and omental fat from obese human subjects compared to their lean controls.

SUBMITTER: Kim Y 

PROVIDER: S-EPMC5920030 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature