Cytokine storms are primarily responsible for the rapid death of ducklings infected with duck hepatitis A virus type 1.

ABSTRACT: Duck hepatitis A virus type 1 (DHAV-1) is one of the most harmful pathogens in the duck industry. The infection of adult ducks with DHAV-1 was previously shown to result in transient cytokine storms in their kidneys. To understand how DHAV-1 infection impacts the host liver, we conducted animal experiments with the virulent CH DHAV-1 strain and the attenuated CH60 commercial vaccine strain. Visual observation and standard hematoxylin and eosin staining were performed to detect pathological damage in the liver, and viral copy numbers and cytokine expression in the liver were evaluated by quantitative PCR. The CH strain (10^8.4 copies/mg) had higher viral titers than the CH60 strain (10^4.9 copies/mg) in the liver and caused ecchymotic hemorrhaging on the liver surface. A

SUBMITTER: Xie J 

PROVIDER: S-EPMC5920089 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature