Synaptic activity-induced glycolysis facilitates membrane lipid provision and neurite outgrowth.

ABSTRACT: The formation of neurites is an important process affecting the cognitive abilities of an organism. Neurite growth requires the addition of new membranes, but the metabolic remodeling necessary to supply lipids for membrane expansion is poorly understood. Here, we show that synaptic activity, one of the most important inducers of neurite growth, transcriptionally regulates the expression of neuronal glucose transporter Glut3 and rate-limiting enzymes of glycolysis, resulting in enhanced glucose uptake and metabolism that is partly used for lipid synthesis. Mechanistically, CREB regulates the expression of Glut3 and Siah2, the latter and LDH activity promoting the normoxic stabilization of HIF-1α that regulates the expression of rate-limiting genes of glycolysis. The expression of dominant-

SUBMITTER: Segarra-Mondejar M 

PROVIDER: S-EPMC5920244 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature