Delayed Initiation of Adjuvant Chemotherapy Among Patients With Breast Cancer.

ABSTRACT:

Importance

Adjuvant chemotherapy improves outcomes of patients with breast cancer. However, the optimal timing of chemotherapy initiation is unknown. Delayed administration can decrease the benefit of cytotoxic systemic therapies.

Objective

To identify the determinants in delayed chemotherapy initiation and to determine the relationship between time to chemotherapy (TTC) and outcome according to breast cancer subtype. We hypothesized that prolonged TTC would be associated with adverse outcomes.

Design, setting, and participants

In an observational, population-based investigation using data from the California Cancer Registry, we studied a total of 24 843 patients with stage I to III invasive breast cancer diagnosed between January 1, 2005, and December 31, 2010, and t

SUBMITTER: Chavez-MacGregor M 

PROVIDER: S-EPMC5920529 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature