Signal intensity analysis and optimization for in vivo imaging of Cherenkov and excited luminescence.

ABSTRACT: During external beam radiotherapy (EBRT), in vivo Cherenkov optical emissions can be used as a dosimetry tool or to excite luminescence, termed Cherenkov-excited luminescence (CEL) with microsecond-level time-gated cameras. The goal of this work was to develop a complete theoretical foundation for the detectable signal strength, in order to provide guidance on optimization of the limits of detection and how to optimize near real time imaging. The key parameters affecting photon production, propagation and detection were considered and experimental validation with both tissue phantoms and a murine model are shown. Both the theoretical analysis and experimental data indicate that the detection level is near a single photon-per-pixel for the detection geometry and frame rates commonly used, w

SUBMITTER: LaRochelle EPM 

PROVIDER: S-EPMC5920648 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature