Overweight duration in older adults and cancer risk: a study of cohorts in Europe and the United States.

ABSTRACT: Recent studies have shown that cancer risk related to overweight and obesity is mediated by time and might be better approximated by using life years lived with excess weight. In this study we aimed to assess the impact of overweight duration and intensity in older adults on the risk of developing different forms of cancer. Study participants from seven European and one US cohort study with two or more weight assessments during follow-up were included (n = 329,576). Trajectories of body mass index (BMI) across ages were estimated using a quadratic growth model; overweight duration (BMI ≥ 25) and cumulative weighted overweight years were calculated. In multivariate Cox models and random effects analyses, a longer duration of overweight was significantly associated with the incidence of obes

SUBMITTER: Arnold M 

PROVIDER: S-EPMC5920679 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature