The Spectrum of Subclinical Primary Aldosteronism and Incident Hypertension: A Cohort Study.

ABSTRACT:

Background

Primary aldosteronism is recognized as a severe form of renin-independent aldosteronism that results in excessive mineralocorticoid receptor (MR) activation.

Objective

To investigate whether a spectrum of subclinical renin-independent aldosteronism that increases risk for hypertension exists among normotensive persons.

Design

Cohort study.

Setting

National community-based study.

Participants

850 untreated normotensive participants in MESA (Multi-Ethnic Study of Atherosclerosis) with measurements of serum aldosterone and plasma renin activity (PRA).

Measurements

Longitudinal analyses investigated whether aldosterone concentrations, in the context of physiologic PRA phenotypes (suppressed, ≤0.50 µg/L per hour; indeterminate, 0.51 to 0.99

SUBMITTER: Brown JM 

PROVIDER: S-EPMC5920695 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature