Coronary artery disease severity modifies associations between glycemic control and both mortality and myocardial infarction.

ABSTRACT:

Aims

This study examined whether the association between hemoglobin A1c (HbA1c) and short-term clinical outcomes is moderated by CAD severity.

Methods

We studied 17,394 US Veterans with type 2 diabetes who underwent elective cardiac catheterization between 2005 and 2013. CAD severity was categorized as obstructive, non-obstructive, or no CAD. Using multivariable Cox proportional hazards regression, we assessed associations between time-varying HbA1c and two-year all-cause mortality and non-fatal MI, with an interaction term between HbA1c and CAD severity.

Results

61%, 22%, and 17% of participants had obstructive, non-obstructive, and no CAD, respectively. CAD severity modified the relationship between HbA1c and each outcome (interaction p-value 0.0005 for mortality an

SUBMITTER: Raghavan S 

PROVIDER: S-EPMC5920719 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature