Re-emergence of yaws after single mass azithromycin treatment followed by targeted treatment: a longitudinal study.

ABSTRACT:

Background

Yaws is a substantial cause of chronic disfiguring ulcers in children in at least 14 countries in the tropics. WHO's newly adopted strategy for yaws eradication uses a single round of mass azithromycin treatment followed by targeted treatment programmes, and data from pilot studies have shown a short-term significant reduction of yaws. We assessed the long-term efficacy of the WHO strategy for yaws eradication.

Methods

Between April 15, 2013, and Oct 24, 2016, we did a longitudinal study on a Papua New Guinea island (Lihir; 16 092 population) in which yaws was endemic. In the initial study, the participants were followed for 12 months; in this extended follow-up study, clinical, serological, and PCR surveys were continued every 6 months for 42 months. We used geno

SUBMITTER: Mitja O 

PROVIDER: S-EPMC5920722 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature