Genetic identification of leptin neural circuits in energy and glucose homeostases.

ABSTRACT: Leptin, a hormone produced in white adipose tissue, acts in the brain to communicate fuel status, suppress appetite following a meal, promote energy expenditure and maintain blood glucose stability^1,2. Dysregulation of leptin or its receptors (LEPR) results in severe obesity and diabetes^3-5. Although intensive studies on leptin have transformed obesity and diabetes research^2,6, clinical applications of the molecule are still limited ⁷ , at least in part owing to the complexity and our incomplete understanding of the underlying neural circuits. The hypothalamic neurons that express agouti-related peptide (AGRP) and pro-opiomelanocortin (POMC) have been hypothesized to be the main first-order, leptin-responsive neurons. Selective deletion of LEPR i

SUBMITTER: Xu J 

PROVIDER: S-EPMC5920723 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature