Hidden heterogeneity in Alzheimer's disease: Insights from genetic association studies and other analyses.

ABSTRACT: Despite evident success in clarifying many important features of Alzheimer's disease (AD) the efficient methods of its prevention and treatment are not yet available. The reasons are likely to be the fact that AD is a multifactorial and heterogeneous health disorder with multiple alternative pathways of disease development and progression. The availability of genetic data on individuals participated in longitudinal studies of aging health and longevity, as well as on participants of cross-sectional case-control studies allow for investigating genetic and non-genetic connections with AD and to link the results of these analyses with research findings obtained in clinical, experimental, and molecular biological studies of this health disorder. The objective of this paper is to perform GWAS o

SUBMITTER: Yashin AI 

PROVIDER: S-EPMC5920782 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature