Cerebellar volume as an imaging marker of development in infants with tuberous sclerosis complex.

ABSTRACT:

Objective

In this cohort analysis, we studied 1-year-old infants with tuberous sclerosis complex (TSC), correlating volumes of cerebellar structures with neurodevelopmental measures.

Methods

We analyzed data from a prospective biomarker study in infants with TSC (ClinicalTrials.gov NCT01780441). We included participants aged 12 months with an identified mutation of TSC1 or TSC2. Using MRI segmentation performed with the PSTAPLE algorithm, we measured relative volumes (structure volume divided by intracranial contents volume) of the following structures: right/left cerebellar white matter, right/left cerebellar exterior, vermal lobules I-V, vermal lobules VI-VII, and vermal lobules VIII-X. We correlated relative volumes to Mullen Scales of Early Learning (MSEL)

SUBMITTER: Srivastava S 

PROVIDER: S-EPMC5921037 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature