Decreased TGFbeta signaling and increased COX2 expression in high risk women with increased mammographic breast density.

ABSTRACT: High mammographic density is associated with a increased risk of breast cancer. We hypothesized that specific pathways exist that are associated with increased mammographic density, and may therefore be used to identify potential targets for chemoprevention. Histologically confirmed normal breast tissue was collected from women undergoing breast surgery who had available demographic data and mammograms for review. Women with low versus high mammographic breast density were compared. Differentially expressed genes using Affymetrix HG U133Plus2 chips were identified in dense versus non-dense tissue. Immunohistochemical analysis (IHC) of estrogen receptor, progesterone receptor, Ki67, and COX2 expression was performed. About 66 women were identified, 28 (42%) had high, and 38 (58%) had low ma

SUBMITTER: Yang WT 

PROVIDER: S-EPMC5921048 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature